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Vaccine Types. 2022 Jan;33 Suppl 27(Suppl 27):58-60. doi: 10.1111/pai.13631. Moderna to build 150m vaccine centre in UK after NHS deal Keep this vaccine out of the sight and reach of children. What are the ingredients in the Moderna COVID-19 Vaccine? Four vaccines are approved by the European Medicines Agency: two messenger RNA-based vaccines encoding the spike protein of SARS-CoV-2 (BNT162b2, Pfizer-BioNTech; mRNA-1273, Moderna) and two adenoviral vector-basedvaccines encoding the spike protein (ChAdOx1 nCoV-19, AstraZeneca; Ad . Lower limb lymphedema and cellulitis as a complication of COVID-19 vaccine: A case report. Australian health minister Greg Hunt in hospital with infection cellulitis after Covid vaccine | Daily Mail Online Grim details of Health Minister Greg Hunt's serious infection are. The cells then make antibodies against the spike protein to help fight off the virus. N Engl J Med. COVID Arm: Delayed Hypersensitivity Reactions to SARS-CoV-2 Vaccines Sixty-year-old woman (patient 1) 24h after initiation of topical steroid treatment; the left arm showed a dramatic decrease in erythema and swelling. Subcutaneous injection can happen inadvertently ( figure 1 ), affecting efficacy of vaccination and potentiate local adverse events. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Medpage Today is among the federally registered trademarks of MedPage Today, LLC and may not be used by third parties without explicit permission. The reactions were first observed during a phase 3 clinical trial of the Moderna vaccine. Single-stranded, 5-capped messenger RNA (mRNA) produced using a cell-free in vitro transcription from the corresponding DNA templates, encoding the viral spike (S) protein of SARS-CoV-2. Disclaimer. In the NEJM letter, the researchers described how and when the skin reaction manifested in people between the ages of 31 and 61the majority of whom were White and female. Although we cannot exclude the possibility that the onset of vasculitis following vaccination was coincidental, striking similarities between these three patients argue for pathogenic causality. -, Belouzard S, Millet JK, Licitra BN, Whittaker GR. No serious reactions were reported. Regulatory approval of Spikevax (formerly COVID-19 Vaccine Moderna) 2022 Jul 16;10(7):1135. doi: 10.3390/vaccines10071135. Q: Does Moderna COVID-19 Vaccine protect against asymptomatic SARS-CoV-2 infection (i.e., the individual is infected with SARS-CoV-2, but does not have signs or symptoms of COVID-19)? The expiry date refers to the last day of that month. If you don't remember your password, you can reset it by entering your email address and clicking the Reset Password button. Monts, France 37260, Moderna Biotech Spain S.L. Why vaccines go into your upper arm and not up your nose The first COVID-19 jabs . While unsightly and uncomfortable, the reactions usually resolve within a few days and do not pose any long-term health risks. Accessed April 28, 2021. "I think this is particularly interesting because it shows that the body is mounting an immune response to the vaccine, just as it does after infection with the virus," said Freeman. By Steven ReinbergHealthDay Reporter. They give you the best protection against COVID-19. GameStop Moderna Pfizer Johnson & Johnson AstraZeneca Walgreens Best Buy Novavax SpaceX Tesla. It is given to adults and children aged 6 years and older. If you get the Moderna COVID-19 vaccine, there is a small chance that you could develop a skin reaction. Interleukin 1alpha: a comprehensive review on the role of IL-1alpha in the pathogenesis and treatment of autoimmune and inflammatory diseases. Moderna's COVID-19 vaccine, also known as mRNA-1273, is a two-dose vaccine. https://www.hhs.gov/immunization/basics/types/index.html. Since the launch of their covid-19 vaccines, Moderna and Pfizer have accumulated more than $100bn (83; 94) in global revenues from salesmore than 20 times the World Health Organization's biennial budget in 2020-21.1 2 3 Yet for a vaccine that is estimated to cost $1-3 per dose to manufacture, both Moderna and Pfizer have announced plans to charge more than $110 a dose in the US this . A randomized, double-blind, placebo-controlled phase III clinical trial to evaluate the efficacy and safety of SARS-CoV-2 vaccine (inactivated, Vero cell): a structured summary of a study protocol for a randomised controlled trial. Among those who received the Moderna vaccine, delayed large local skin reactions were most common, occurring in 175 of 267 (66%) patients after the first dose and 31 of 102 (30%) after the. Unlike cellulitis that tends to progress, or worsen over time, symptoms of skin reactions to COVID-19 vaccines tend to not progress, according a few case reports of vaccine reactions misdiagnosed as cellulitis that were published in the Journal of Primary Care & Community Health. Established in March 2020 to accumulate information on cutaneous manifestations of COVID-19, the registry expanded in December to include vaccine-related skin reactions, shortly after the FDA issued the first emergency use authorizations (EUAs) for the vaccines. Cellulitis staphylococcal (a type of bacteria originated skin soft tissue infection) is found to be associated with 555 drugs and 257 conditions by eHealthMe. There are two main COVID-19 vaccines: Pfizer-BioNTech and Moderna. 2021:384(5). See the end of section 4 for how to report side effects. All information is observation-only. Hyponatraemic encephalopathy and Vulval cellulitis - eHealthMe Privacy PolicyTerms and ConditionsAccessibility, Unit of Immunology, Rheumatology, Allergy and Rare Diseases, IRCCS San Raffaele Scientific Institute, Milan 20132, Italy, Division of Rheumatology, Department of Clinical Internal, Anaesthesiologic and Cardiovascular Sciences, Sapienza University, Rome, Italy, Department of Pathology, IRCCS San Raffaele Scientific Institute, Milan 20132, Italy. Covid vaccines linked to four different skin reactions - from - The Sun Moderna COVID-19 Vaccine Overview: What You Need to Know - Healthline 2022 Sep 27;9(10):ofac499. PMC Journal of the American Academy of Dermatology. The site is secure. Clin Case Rep. 2022 Sep 12;10(9):e6314. Please include "Moderna COVID-19 Vaccine EUA" or "Moderna COVID-19 Vaccine, Bivalent EUA", as appropriate, in the first line of box #18 of the report form. Reactions to the Moderna COVID-19 vaccine usually happen within 4 hours of injection. A shot in the dark - American Academy of Dermatology Dont include personal or financial information like your National Insurance number or credit card details. Spikevax (previously COVID-19 Vaccine Moderna) Normal skin can be affected by cellulitis, but it usually happens after some type of injury causes a skin break, including trauma or surgery. COVID-19 vaccine-induced cellulitis and myositis If you get any side effects, talk to your doctor, pharmacist or nurse. What's the New Phenomenon Called "COVID Vaccine Arm"? V-safe is a new voluntary smartphone-based tool that uses . have a high fever or severe infection; however, you can have your vaccination if you have a mild fever or upper airway infection like a cold. If side effects such as pain and/or fever are troublesome, they can be treated by medicines for pain and fever such as paracetamol. A new study finds some of them, including COVID toes, a measleslike rash and shingles also can be rare, and thankfully brief, side . Charles Bankhead, Senior Editor, MedPage Today There are no data to assess the concomitant administration of Spikevax with other vaccines. The Moderna COVID-19 Vaccine should be transported in the frozen state. Published 2021. The Moderna COVID-19 Vaccine includes the following ingredients: Active ingredient. Spikevax is a vaccine used to prevent COVID-19 caused by SARS-CoV-2. Spikevax is also available as two adapted . Talk to your doctor, pharmacist or nurse before you are given Spikevax if you: There is an increased risk of myocarditis (inflammation of the heart muscle) and pericarditis (inflammation of the lining outside the heart) after have been vaccination with Spikevax (see section 4). It is created by eHealthMe based on reports of 392,577 people who have side effects while getting Moderna COVID Vaccine from the CDC and the FDA, and is updated regularly. Delayed localized hypersensitivity reactions to the Moderna COVID-19 vaccine: a case series. Key Points. Vaccines against SARS-CoV-2 represent a pivotal and effective countermeasure to contain the COVID-19 pandemic. Do not drive or use machines if you are feeling unwell after vaccination. "There may be genetic factors at playwe know that genetics can be a risk for certain T-cell reactions to drugsbut otherwise, we dont fully understand why someone has a response while another does [not] for most drugs and vaccines.". Moderna COVID-19 6 5 : . We use cookies to help provide and enhance our service and tailor content and ads. Moderna's Covid-19 vaccine can cause skin reactions 11 DAYS after jab Specifically, vasculitis developed in healthy individuals with no personal or family history of autoimmunity; clinical manifestations were similar and characterised by widespread cutaneous vasculitis with no visceral involvement; and there was a temporal association between vaccination and the development of clinical manifestations, with no other intercurrent inciting events. One dose (0.5 mL) contains 100 micrograms of messenger RNA (mRNA) (embedded in SM-102 lipid nanoparticles). The Lancet Regional Health Southeast Asia, The Lancet Regional Health Western Pacific, B cells: more than just for antibodies in SARS-CoV-2 vaccine responses, Haemophagocytic lymphohistiocytosis secondary to COVID-19: a case series, We use cookies to help provide and enhance our service and tailor content and ads. 18 Rue de Montbazon Spikevax will be given to you as two 0.5 mL injections. The study said they were associated with younger patients, lasted for an average of 12.7 days, appeared later in the course of COVID-19 and were associated with less severe cases of the disease. However, laboratory tests showed only non-specific increases in erythrocyte sedimentation rate and C-reactive protein (CRP); anti-neutrophil cytoplasmic antibodies, cytoplasmic anti-neutrophil cytoplasmic antibodies, perinuclear anti-neutrophil cytoplasmic antibodies, rheumatoid factor, cryoglobulins, antinuclear antibodies, anti-DNA, C3, C4, IgA, and serology for hepatitis B virus and hepatitis C virus were negative or normal. Dont worry we wont send you spam or share your email address with anyone. They also stress that concerns about a skin reaction should not keep people from getting vaccinated. The initial report was limited to skin reactions associated with the Moderna and Pfizer vaccines, the only two with EUAs at the time of data analysis. In addition, your close contacts J Cosmet Dermatol. You have rejected additional cookies. Paseo de Europa, 50 Vaccines against SARS-CoV-2 represent a pivotal and effective countermeasure to contain the COVID-19 pandemic. BMC Infect Dis. Frequency of the most common manifestations of local injection-site reactions, by dose, were swelling (18% and 15%), erythema (18% and 20%), and pain (24% and 18%). The authors noted that it's possible that redness gets overlooked or may not be as obvious on dark skin. Sanomachi T, Sumiyoshi Okuma H, Yonemori K. Int Cancer Conf J. In: Mandell GL, Bennett JE, Dolin R. (eds) Principles and Practice of Infectious Diseases. Local injection-site reactions occurred in 54% of patients after the first Moderna dose and 70% after the second dose. The Covid-19 vaccine is one example of how mRNA can be used. Administration of Moderna COVID-19 Vaccines | CDC The term "COVID arm" has been coined to describe a harmless delayed hypersensitivity reaction occurring approximately a week after administration of the novel SARS-CoV-2 mRNA vaccine. If you have itching, swelling, or tenderness at the injection site in the days after getting either dose of the vaccine, don't panic. Painful, pruritic, indurated, erythematous plaque, Painful, pruritic, indurated, erythematous plaque with minute papules inferior to ecchymoses at the, Sixty-year-old woman (patient 1) 24 h after initiation of topical steroid treatment; the, Pruritic, painful, erythematous, indurated plaque, Pruritic, painful, erythematous, indurated plaque at vaccine site in a 44-year-old woman (patient, Erythematous, pruritic, painful, indurated plaque, Erythematous, pruritic, painful, indurated plaque in a 33-year-old woman (patient 3) 7 days, MeSH All patients underwent serologic testing for SARS-CoV-2 infection before vaccination and tested negative, indicating no previous primary infection: hence, vasculitis might have been triggered by maladaptive individual immune responses to a component of the vaccine. Successful Treatment of Delayed Localized Necrotizing Inflammatory Myositis After Severe Acute Respiratory Syndrome Coronavirus 2 mRNA-1273 Vaccine: A Case Report. This includes any possible side effects not listed in this leaflet. Do not throw away any medicines via wastewater or household waste. Clipboard, Search History, and several other advanced features are temporarily unavailable. "Ice can also be helpful for the swelling and pain at the site.". 2021;384:403-416. Mechanisms of coronavirus cell entry mediated by the viral spike protein. Tel: 0800 085 7562. By reporting side effects you can help provide more information on the safety of this vaccine. The vaccine must be administered intramuscularly. DOCX Moderna COVID-19 vaccine for children aged 6 months to 5 years What you need to know before you are given Spikevax, Contents of the pack and other information, Check benefits and financial support you can get, Find out about the Energy Bills Support Scheme, Regulatory approval of Spikevax (formerly COVID-19 Vaccine Moderna), Package leaflet: Information for the user, The following information is intended for healthcare professionals only, nationalarchives.gov.uk/doc/open-government-licence/version/3. Disclaimer. doi:10.1056/NEJMoa2035389, Robinson LB, Fu X, Hashimoto D, et al. 2021 Sep;20(9):2684-2690. doi: 10.1111/jocd.14312. Global prevalence and clinical manifestations of cutaneous adverse reactions following COVID-19 vaccination: A systematic review and meta-analysis. Given the considerable potential for confusion, the researchers called for increased awareness of these skin reactions to help avoid needless diagnostic testing and treatment. FOIA Clinicians can distinguish SARS-CoV-2 vaccine reactions from cellulitis by the time of onset (approximately a week vs 5 days), by the lack of progression of symptoms, and resolution over 4 to 5 days. Severe cases of COVID arm may be treated with topical steroids. Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. Lipid SM-102 (heptadecan-9-yl 8-{(2-hydroxyethyl)[6-oxo-6-(undecyloxy)hexyl]amino}octanoate), 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC), 1,2-Dimyristoyl-rac-glycero-3-methoxypolyethylene glycol-2000 (PEG2000 DMG). The study is based on data from the CDC and the FDA. Moderna COVID-19 Vaccine Information from Drugs.com Bethesda, MD 20894, Web Policies Cutaneous adverse reactions following COVID-19 vaccinations: A systematic review and meta-analysis. If you are immunocompromised, you may receive a third dose of Spikevax. Financing covid-19 mRNA vaccines | The BMJ Delayed large local reactions occurred after 15% of first doses and after 18% of second doses. headache, muscle pain, joint pain. Freeman disclosed a relevant relationship with UpToDate. Departments, agencies and public bodies. Additionally, five people died after receiving a jab from an. You can help by reporting any side effects you may get. Very large clinical trials have shown that Moderna is effective in preventing COVID-19 in people aged 12 years and older. As a physician, I knew the possible side-effects of the new Moderna COVID-19 vaccine: fever, muscle pain, local redness, local swelling and axillary (arm pit) lymph nodes, but those were. Spikevax may affect the way other medicines work, and other medicines may affect how Spikevax works. National Library of Medicine For any information about this medicine, please contact the local representative of the Marketing Authorisation Holder. With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. If you do develop one, don't panic. This site needs JavaScript to work properly. The Pfizer subgroup represented a smaller sample size (34 first-dose reports and 40 second-dose reports), but the pattern of skin reactions was similar to that observed with the Moderna vaccine. stroking or scratching the skin), Menstrual disorder (disease of menstrual cycle), Menstruation delayed (late menstruation cycle), Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability), Mental impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition), Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation), Micturition urgency (urgency to pass the urine), Mobility decreased (ability to move is reduced), Monoplegia (a paralysis of a single limb), Mood swings (an extreme or rapid change in mood), Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness), Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. Moderna Inc will make certain contingent development, commercial and regulatory milestone payments to the U.S. National Institutes of Health (NIH) related to the development of COVID-19 vaccines . Nature: Covid Vaccination Linked to 21% Average Increase in a Large It can also develop around the eyes, mouth, and anus, or on the belly. 2021;12:215013272110244. doi:10.1177/21501327211024431, Baden L, El Sahly H, Essink B, et al. The vaccine comes ready to use once thawed. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Accessibility Epub 2020 Jul 23. The clinical features of the patients are summarised in the, All cases were investigated for laboratory abnormalities or organ involvements that are typically associated with small-vessel vasculitis. We have a lot of things that are delayed hypersensitivity, like eczema, contact dermatitis, common antibiotic rashes," Blumenthal says. Spikevax will be given to you as two 0.25 mL injections. Ten (10) doses (of 0.5mL each) or a maximum of twenty (20) doses (of 0.25mL each) can be withdrawn from each multidose vial. Guidance and regulation Efficacy and safety of the mRNA-1273 SARS-CoV-2 vaccine: supplementary appendix. Who can get a COVID-19 vaccine Everyone aged 5 (on or before 31 August 2022) and over can get a 1st and 2nd dose of the COVID-19 vaccine. Worm M, Alexiou A, Bauer A, Treudler R, Wurpts G, Dickel H, Buhl T, Mller S, Jung A, Brehler R, Fluhr J, Klimek L, Mlleneisen N, Pftzner W, Raap U, Roeseler S, Schuh S, Timmermann H, Heine G, Wedi B, Brockow K. Allergy. a skin reaction that causes red spots or patches on the skin that may look like a target or bulls eye with a dark red centre surrounded by paler red rings (erythema multiforme). Moderna COVID Vaccine and Cellulitis staphylococcal - a phase IV clinical study of CDC and FDA data Summary: Cellulitis staphylococcal is reported only by a few people who get Moderna COVID Vaccine. QJM. Spikevax (Moderna) | Australian Government Department of Health and Covid Vaccination Linked to 21% Average Increase in a Large Number of Medical Problems. Opens in a new tab or window, Share on Twitter. Epub 2022 Jun 21. Washrawirul C, Triwatcharikorn J, Phannajit J, Ullman M, Susantitaphong P, Rerknimitr P. J Eur Acad Dermatol Venereol. Madrid 28002 Baden LR, El Sahly HM, Essink B, et al.. Efficacy and safety of the mRNA-1273 SARS-CoV-2 vaccine. Bethesda, MD 20894, Web Policies A wide range of skin reactions has occurred following coronavirus vaccination -- including some that mimic COVID-19 symptoms -- but none proved to be serious, according to initial data from an international registry. N Engl J Med. A carton of Moderna COVID19 Vaccine contains 10 multiple-dose vials. Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines. Pierce the stopper preferably at a different site each time. official website and that any information you provide is encrypted General side effects: fatigue, headache, muscle pain, joint pain, chills, nausea and vomiting, and fever. This includes any possible side effects not listed in this leaflet. Use of this site constitutes acceptance of eHealthMe.com's terms of service and privacy policy. Your doctor, pharmacist or nurse will inject the vaccine into a muscle (intramuscular injection) in your To update your cookie settings, please visit the Cookie Preference Center for this site. A third dose may be given at least 1 month after the second dose to individuals 12 years of age and older (0.5 mL, 100 micrograms) and children 6 through 11 years (0.25 mL, 50 micrograms) who are severely immunocompromised. A case includes 12 cartons, or a total of 120 vials. Copyright 2023 Elsevier Inc. except certain content provided by third parties. newsGP - ATAGI gives Moderna bivalent vaccine green light - racgp.org.au Berg S. What doctors wish patients knew about the Johnson & Johnson vaccine. See section 4. you are allergic to the active substance or any of the other ingredients of this vaccine, listed in, have previously had a severe, life-threatening allergic reaction after any other vaccine injection or after you were given Spikevax in the past, have a very weak or compromised immune system. Madrid, Spain, Recipharm Monts Storage & Handling | Moderna COVID-19 Vaccine (EUA) As with any vaccine, the primary 2-dose vaccination course of Spikevax may not fully protect all those who receive it and it is not known how long you will be protected. Myositis ossificans following COVID-19 vaccination. COVID vaccines that are related to Vulval cellulitis: Vulval cellulitis in Moderna COVID Vaccine; Vulval cellulitis in Pfizer BioNTech Covid Vaccine; Vulval cellulitis in Johnson and Johnson Covid Vaccine The content on this site is intended for healthcare professionals. Moderna's Omicron vaccine: When it will be available and who can get it Those carrying cross-reactive T cells from earlier exposure to other coronaviruses had greater immune responses after vaccination. For the primary series, Spikevax should be administered as two 0.5 mL (100 microgram) doses for individuals 12 years of age and older. doi: 10.1002/ccr3.6317. feeling faint or light-headed changes in your heartbeat shortness of breath wheezing swelling of your lips, face, tongue or throat hives or rash nausea or vomiting stomach pain Talk to your doctor. Thawed vials and filled syringes can be handled in room light conditions. American Medical Association. This site needs JavaScript to work properly. This article will explore what skin reactions to the Moderna COVID-19 vaccine look like, how common they are, and what to do if you get one. Our website is not intended to be a substitute for professional medical advice, diagnosis, or treatment. In addition, you can report side effects to ModernaTX, Inc. at 1-866-663-3762. This will help to protect you against COVID-19. In a study published in the NEJM in February, 2021, the investigators reported that 12,765 (84.2%) of the 15,168 participants who had received the vaccine rather than the placebo developed an immediate skin reaction after receiving their first dose of the vaccine. The delayed skin reactions described in the reports often resembled the raised, red welts that are caused by an insect sting. Adverse events after first COVID-19 vaccination in patients with autoimmune diseases. Among those who had a skin reaction after the first dose, 11 people also had a similar reaction after their second dose. . Moderna on Friday filed patent infringement lawsuits against Pfizer and BioNTech "for infringing patents central to (its) mRNA technology platform," the company said in a news release Friday. According to the report, 472 people died after receiving a Moderna vaccine, while 489 died after receiving a Pfizer vaccine. it damages the myelin sheath), Muscle contractions involuntary (uncontrolled muscle contraction), Muscle strain (an injury to a muscle in which the muscle fibres tear), Musculoskeletal chest pain (pain in chest muscle or nerve or bones), Musculoskeletal discomfort (discomfort in the body's muscles, joints, tendons, ligaments and nerves), Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves), Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves), Myocarditis (inflammation of heart muscle myocardium), Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels), Nasopharyngitis (inflammation of the nasopharynx), Nausea (feeling of having an urge to vomit), Nervous system disorder (a general class of medical conditions affecting the nervous system), Neurological symptom (symptoms of nervous system disease), Neuropathy peripheral (surface nerve damage), Neutrophil count increased (excess than normal number of neutrophil a type of blood cell), Numbness and tingling (unusual prickling sensations), Ocular discomfort (a generic expression when there is lack of ease in/about the eyes), Ocular hyperaemia (an abnormally large amount of blood in eye), Oral discomfort (pain or irritation in mouth), Oropharyngeal discomfort (pain or irritation of oropharynx), Osteoarthritis (a joint disease caused by cartilage loss in a joint), Paleness (unusual lightness of skin colour), Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect), Paraesthesia oral (sensation of tingling, tickling, prickling, pricking, or burning of a person's oral with no apparent long-term physical effect), Parosmia (distortion of the sense of smell, as in smelling odours that are not present), Periarthritis (inflammation of the external coats of an artery and of the tissues around the artery), Pericardial effusion (fluid around the heart), Pericarditis (inflammation of the pericardium), Pharyngeal hypoaesthesia (pharyngeal -abnormally decreased sensitivity), Photophobia (extreme sensitivity to light), Photopsia (presence of perceived flashes of light), Pneumonia bacterial (pneumonia associated with bacterial infection), Pollakiuria (abnormally frequent passage of relatively small quantities or urine), Polymyalgia rheumatica (pain in many muscles), Postmenopausal haemorrhage (post-menopausal bleeding), Psoriasis (immune-mediated disease that affects the skin), Pulmonary congestion (congestion in the lungs), Pulmonary embolism (blockage of the main artery of the lung), Pulmonary oedema (fluid accumulation in the lungs), Pulmonary thrombosis (scarring in the lungs), Purpura (purplish discoloration of the skin), Rash maculo-papular (red area on the skin that is covered with small confluent bumps), Rash vesicular (rash with a small bubble), Red blood cell sedimentation rate increased, Renal impairment (severely reduced kidney function), Respiratory acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease), Respiratory disorder (respiratory disease), Respiratory distress (difficulty in breathing), Respiratory rate increased (excess breathing rate/min), Respiratory syncytial virus test negative, Respiratory tract congestion (blockage on respiratory system), Restless leg syndrome (a powerful urge to move your legs), Retching (strong involuntary effort to vomit), Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down), Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints), Rotator cuff syndrome (a spectrum of conditions affecting the rotator cuff tendons of the shoulder), Salivary hypersecretion (excess saliva secretion), Scab (a hard coating on the skin formed during the wound healing), Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve), Scleroma (a hardened patch of tissue in the skin or mucous membranes), Seizure like phenomena (a variety of medical conditions may produce sudden episodes which have some similarities to epileptic seizures), Seizures (abnormal excessive or synchronous neuronal activity in the brain), Sepsis (a severe blood infection that can lead to organ failure and death), Septic shock (shock due to blood infection), Shock (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin), Sinus headache (headache caused by sinus infections), Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node), Skin blushing/flushing (a sudden reddening of the face, neck), Skin discoloration - bluish (bluish colour of skin), Skin exfoliation (removal of the oldest dead skin cells), Skin induration (an abnormally hard spot or area on the skin), Speech impairment (adult) (inability to speak (adult)), Stomatitis (inflammation of mucous membrane of mouth), Stroke (sudden death of a portion of the brain cells due to a lack of oxygen), Supraventricular extrasystoles (premature electrical impulse in the heart, generated above the level of the ventricle), Systemic lupus erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue), Tenderness (pain or discomfort when an affected area is touched), Tendonitis (a condition that causes pain and swelling of tendons), The flu (the flu is caused by an influenza virus), Thrombocytopenia (decrease of platelets in blood), Thrombosis (formation of a blood clot inside a blood vessel), Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow)), Tremor (trembling or shaking movements in one or more parts of your body), Trigeminal neuralgia (a painful condition of the nerve responsible for most facial sensation), Tunnel vision (the loss of peripheral vision with retention of central vision), Type iv hypersensitivity reaction (delayed type hypersensitivity as the reaction takes two to three days to develop), Urinary incontinence (inability to control the flow of urine and involuntary urination), Urinary retention (the inability to completely or partially empty the bladder), Urticaria (rash of round, red welts on the skin that itch intensely), Urticaria chronic (long lasting rash of round, red welts on the skin that itch intensely), Vaccination site erythema (redness around vaccination site), Vaccination site lymphadenopathy (abnormal enlargement of the lymph nodes- vaccination site), Vaccination site pruritus (severe itching of the skin at vaccination site), Vasculitis (inflammation of a blood vessel or blood vessels), Ventricular extrasystoles (premature cardiac contraction), Ventricular tachycardia (rapid heartbeat that originates in one of the lower chambers (the ventricles) of the heart), Vitreous floaters (spots before the eyes), Wheezing (a high-pitched whistling sound made while you breath), Simvastatin and Anaemia Of Chronic Disease, Cytarabine and Therapeutic Agent Toxicity, Lansoprazole and Injection Site Urticaria, Staphylococcus Test Positive: 1 person, 50.00%, Staphylococcal Infection (an infection with staphylococcus bacteria): 1 person, 50.00%, Periorbital Cellulitis (inflammation and infection of the eyelid and the skin surrounding the eye): 1 person, 50.00%, Muscle Aches (muscle pain): 1 person, 50.00%, Culture Wound Positive: 1 person, 50.00%, Cellulitis (infection under the skin): 1 person, 50.00%.